【中華．了解多一點】抑鬱症女科學家—胡海嵐
Emotions color our lives and profoundly shape the way we think and behave. Research in my lab aims to understand how emotional and social behaviors are encoded in the brain, with a main focus on the neural circuitry underlying depression and social dominance. Specifically we are looking into three major problems: First, we study how the brain represents emotions of different valence. Through simultaneously mapping the neural activity response to rewarding and aversive stimuli in the same mouse brain and at single cell resolution, we have identified a functional valence map. Second, we search for the molecular and circuit mechanism of depression, focusing on a brain region called habenula, which encodes negative reward. We have identified several key habenula-expressing molecules that play important roles in the etiology of depression. Third, we establish animal models for studying social hierarchy in mice and explore the neural mechanism underlying the dominance trait. We are recording and manipulating neural activity during social competition to study how dominance hierarchy arises from interplay between the activity of specific neural circuits and social experience such as history of winning or losing. We are tackling these problems using combinatorial cutting-edge techniques including imaging, electrophysiology (both in vitro and in vivo), molecular genetics and optogenetic. We hope that these studies will shed new light on the neural basis of some essential emotional and social behaviors, and provide therapeutic implications for the treatment of emotional disorders. http://www.hailanhu-lab.net/index.php?c=article&a=type&tid=26
為什麼我們能夠感受到快樂、愛、恐懼、憤怒和焦慮？情感和理性在大腦中如何相互影響和對抗？各種各樣的情感不僅使我們的生活充滿色彩，也深刻地影響我們的行為和抉擇。同時作為社會性動物，我們的情緒和健康又受到多種社會行為的調節。我們研究組致力於研究情緒與社會行為的神經基礎與可塑性機制。我們將利用最前沿的電生理、光遺傳學、細胞和分子生物學等多層面研究手段，應用離體腦片和整體動物模型對情緒相關的神經環路進行細胞和環路層面的研究。
Professor Hailan Hu
1992-1996 B.S., Beijing University
1997-2002 Ph.D., Univ. of California Berkeley
2003-2004 Post doctor, University of Virginia, with Julius Zhu and Roberto Malinow
2004-2008 Post doctor, Cold Spring Harbor Laboratory/UCSD, with Roberto Malinow
2009-2015 Principal Investigator, Institute of Neuroscience, CAS
2015- Professor, School of Medicine, Zhejiang University
科學沒有國界，但是科學家有祖國。神經科學家胡海嵐曾在美國深造，並有著一位能讓她輕鬆獲得學術成功的導師，可是她最終決定跳出「舒適圈」，返回中國創辦實驗室，更國家培養人才，獲得斐然的學術成就，得到被譽為「女性諾貝爾獎」的「世界傑出女科學家成就獎」。
今集《中華‧了解多一點》中，主持人周天慧為大家介紹胡海嵐是如何將自己畢生所學貢獻國家、救助有需要的抑鬱症患者。
0:00 傑出女科學家胡海嵐
3:14 毅然棄美報效國家
5:58 創建實驗室培育人才
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