WE 中華頻道

Mechanisms of Cell Death 细胞死亡

Understanding the Molecular Mechanisms of Cell Death. 2026.09.30

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美籍院士袁钧瑛解释细胞死亡真相，读博期间辅助导师研究细胞衰亡课题，成功斩获诺贝尔奖！

Dr. Junying Yuan is a world-renowned Chinese-American cell biologist and member of the U.S. National Academy of Sciences. She is best known for her groundbreaking contributions to understanding the molecular mechanisms of cell death.

Key Highlights & Career Achievements

Pioneering Cell Death Research: Early in her career, while completing her Ph.D. under the supervision of MIT professor H. Robert Horvitz (who later won the 2002 Nobel Prize for his work on cell death), Yuan identified key genes and mammalian enzymes (such as caspases) that control programmed cell death, or apoptosis.
Discovery of Necroptosis: She later discovered necroptosis, a controlled/programmed form of necrotic cell death, and developed small-molecule inhibitors (necrostatins) to target it.
Academic Leadership: She was appointed as the Elizabeth D. Hay Professor of Cell Biology at Harvard Medical School before returning to Shanghai to direct the Interdisciplinary Research Center on Biology and Chemistry at the Chinese Academy of Sciences.
Therapeutic Impact: Her research into RIPK1 inhibitors and cellular degradation pathways has advanced into human clinical trials for treating neurodegenerative and inflammatory conditions, such as ALS and Alzheimer's disease.

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